Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …

The approach of peptide-based anticancer vaccination has proven the ability to induce
cancer-specific immune responses in multiple studies for various cancer entities. However …

Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

Cancer greatly affects the quality of life of humans worldwide and the number of patients
suffering from it is continuously increasing. Over the last century, numerous treatments have …

Colorectal cancer is the third most common and the second deadliest cancer worldwide. To
date, colorectal cancer becomes one of the most important challenges of the health system …

Background Clinically, prophylactic anti-recurrence treatments for hepatocellular carcinoma
(HCC) patients after radical surgery are extremely limited. Neoantigen based vaccine can …

Neoantigen vaccines are based on epitopes of antigenic parts of mutant proteins expressed
in cancer cells. These highly immunogenic antigens may trigger the immune system to …

Despite advances in predicting physical peptide-major histocompatibility complex I (pMHC I)
binding, it remains challenging to identify functionally immunogenic neoepitopes, especially …

Targeted therapy and immunotherapy in combination is considered the ideal strategy for
treating metastatic cancer, as it can eliminate the primary tumors and induce host immunity …

Simple Summary Pancreatic cancer remains one of the most challenging malignancies to
treat with standard approaches. Emerging treatment approaches incorporating innovative …