The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection
The availability of the first molecular clone of the hepatitis C virus (HCV) genome allowed
the identification and biochemical characterization of two viral enzymes that are targets for …
the identification and biochemical characterization of two viral enzymes that are targets for …
Replication of hepatitis C virus
D Moradpour, F Penin, CM Rice - Nature reviews microbiology, 2007 - nature.com
Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …
Hepatitis C virus proteins: from structure to function
D Moradpour, F Penin - Hepatitis C virus: from molecular virology to …, 2013 - Springer
Great progress has been made over the past years in elucidating the structure and function
of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as …
of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as …
Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing
P Dzeja, A Terzic - International journal of molecular sciences, 2009 - mdpi.com
Adenylate kinase and downstream AMP signaling is an integrated metabolic monitoring
system which reads the cellular energy state in order to tune and report signals to metabolic …
system which reads the cellular energy state in order to tune and report signals to metabolic …
Flaviviral NS4b, chameleon and jack‐in‐the‐box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention
Dengue virus and other flaviviruses such as the yellow fever, West Nile, and Japanese
encephalitis viruses are emerging vector‐borne human pathogens that affect annually more …
encephalitis viruses are emerging vector‐borne human pathogens that affect annually more …
Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory
J Gouttenoire, F Penin… - Reviews in medical …, 2010 - Wiley Online Library
Hepatitis C virus (HCV) is a positive‐strand RNA virus that replicates its genome in a
membrane‐associated replication complex. Nonstructural protein 4B (NS4B) induces the …
membrane‐associated replication complex. Nonstructural protein 4B (NS4B) induces the …
NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus
SA Shiryaev, AV Chernov… - Journal of General …, 2009 - microbiologyresearch.org
Using constructs that encode the individual West Nile virus (WNV) NS3helicase (NS3hel)
and NS3hel linked to the hydrophilic, N-terminal 1–50 sequence of NS4A, we demonstrated …
and NS3hel linked to the hydrophilic, N-terminal 1–50 sequence of NS4A, we demonstrated …
Development of novel therapies for hepatitis C
The current standard of care for the treatment of hepatitis C virus (HCV) infection is a
combination of pegylated IFN and ribavirin (Peg-IFN/RBV). Because of the adverse effects …
combination of pegylated IFN and ribavirin (Peg-IFN/RBV). Because of the adverse effects …
A journey around the medicinal chemistry of hepatitis C virus inhibitors targeting NS4B: from target to preclinical drug candidates
Hepatitis C virus (HCV) infection is a global health burden with an estimated 130–170
million chronically infected individuals and is the cause of serious liver diseases such as …
million chronically infected individuals and is the cause of serious liver diseases such as …
Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function
M Gu, CM Rice - Current opinion in virology, 2013 - Elsevier
Highlights•Membrane-associated positive-strand RNA virus replication.•HCV NS proteins
involved in replicase assembly and function.•Structures, mechanisms and functional …
involved in replicase assembly and function.•Structures, mechanisms and functional …