Stroke related to large vessel occlusion is a leading cause of disability and death worldwide.
Advances in endovascular therapy to reopen occluded arteries have been shown to reduce …

Approximately one-third of acute ischemic strokes with an identifiable vessel occlusion are
caused by medium vessel occlusion (MeVO), that is, nonlarge vessel occlusions that are …

Background The use of thrombectomy in patients with acute stroke and a large infarct of
unrestricted size has not been well studied. Methods We assigned, in a 1: 1 ratio, patients …

Importance Whether endovascular thrombectomy (EVT) efficacy for patients with acute
ischemic stroke and large cores varies depending on the extent of ischemic injury is …

Importance Recent large infarct thrombectomy trials used heterogeneous imaging
modalities and time windows for patient selection. Noncontrast computed tomographic (CT) …

Background Multiple randomised trials have shown efficacy and safety of endovascular
thrombectomy in patients with large ischaemic stroke. The aim of this study was to evaluate …

Importance Endovascular therapy (EVT) demonstrated better outcomes compared with
medical management in recent randomized clinical trials (RCTs) of patients with large …

Importance Recently, 6 randomized clinical trials—RESCUE-Japan-LIMIT (Recovery by
Endovascular Salvage for Cerebral Ultra-Acute Embolism—Japan Large Ischemic Core …

BACKGROUND: Recent large core trials have highlighted the effectiveness of mechanical
thrombectomy (MT) in acute ischemic stroke with large vessel occlusion. Variable perfusion …

Summary Background In the ESCAPE-NA1 trial, treatment with nerinetide, an eicosapeptide
that interferes with post-synaptic density protein 95, was associated with improved functional …