Using clusterProfiler to characterize multiomics data

S Xu, E Hu, Y Cai, Z **e, X Luo, L Zhan, W Tang… - Nature protocols, 2024 - nature.com
With the advent of multiomics, software capable of multidimensional enrichment analysis
has become increasingly crucial for uncovering gene set variations in biological processes …

Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula

L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …

A pan-cancer single-cell panorama of human natural killer cells

F Tang, J Li, L Qi, D Liu, Y Bo, S Qin, Y Miao, K Yu… - Cell, 2023 - cell.com
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor
progression. To depict their phenotypic and functional diversities in the tumor …

Sangerbox: a comprehensive, interaction‐friendly clinical bioinformatics analysis platform

W Shen, Z Song, X Zhong, M Huang, D Shen, P Gao… - Imeta, 2022 - Wiley Online Library
In recent decades, with the continuous development of high‐throughput sequencing
technology, data volume in medical research has increased, at the same time, almost all …

ApoE isoform–and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

D Seo, D O'Donnell, N Jain, JD Ulrich, J Herz, Y Li… - Science, 2023 - science.org
Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease. Primary tauopathies
are characterized by pathological tau accumulation and neuronal and synaptic loss …

Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment

KM Tharp, K Kersten, O Maller, GA Timblin, C Stashko… - Nature cancer, 2024 - nature.com
Tumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix
accumulation, which is associated with diminished antitumor immune infiltration. Here we …

Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment

XY He, Y Gao, D Ng, E Michalopoulou, S George… - Cancer Cell, 2024 - cell.com
Chronic stress is associated with increased risk of metastasis and poor survival in cancer
patients, yet the reasons are unclear. We show that chronic stress increases lung metastasis …

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

A Filliol, Y Saito, A Nair, DH Dapito, LX Yu… - Nature, 2022 - nature.com
Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide,
develops almost exclusively in patients with chronic liver disease and advanced fibrosis …

Majorbio Cloud: a one‐stop, comprehensive bioinformatic platform for multiomics analyses

Y Ren, G Yu, C Shi, L Liu, Q Guo, C Han, D Zhang… - IMeta, 2022 - Wiley Online Library
The rapid developments of high‐throughput sequencing technology in the last decade
allowed the emergence of multiomics analyses. Analytic platforms for high‐throughput omics …