Using clusterProfiler to characterize multiomics data
With the advent of multiomics, software capable of multidimensional enrichment analysis
has become increasingly crucial for uncovering gene set variations in biological processes …
has become increasingly crucial for uncovering gene set variations in biological processes …
Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula
L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …
systems biology theory, biological system network analysis, and multi-target drug molecule …
Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology
Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …
molecular and cellular mechanisms underlying cognitive impairment remain poorly …
A pan-cancer single-cell panorama of human natural killer cells
F Tang, J Li, L Qi, D Liu, Y Bo, S Qin, Y Miao, K Yu… - Cell, 2023 - cell.com
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor
progression. To depict their phenotypic and functional diversities in the tumor …
progression. To depict their phenotypic and functional diversities in the tumor …
Sangerbox: a comprehensive, interaction‐friendly clinical bioinformatics analysis platform
W Shen, Z Song, X Zhong, M Huang, D Shen, P Gao… - Imeta, 2022 - Wiley Online Library
In recent decades, with the continuous development of high‐throughput sequencing
technology, data volume in medical research has increased, at the same time, almost all …
technology, data volume in medical research has increased, at the same time, almost all …
ApoE isoform–and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy
Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease. Primary tauopathies
are characterized by pathological tau accumulation and neuronal and synaptic loss …
are characterized by pathological tau accumulation and neuronal and synaptic loss …
Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment
Tumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix
accumulation, which is associated with diminished antitumor immune infiltration. Here we …
accumulation, which is associated with diminished antitumor immune infiltration. Here we …
Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment
Chronic stress is associated with increased risk of metastasis and poor survival in cancer
patients, yet the reasons are unclear. We show that chronic stress increases lung metastasis …
patients, yet the reasons are unclear. We show that chronic stress increases lung metastasis …
Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis
Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide,
develops almost exclusively in patients with chronic liver disease and advanced fibrosis …
develops almost exclusively in patients with chronic liver disease and advanced fibrosis …
Majorbio Cloud: a one‐stop, comprehensive bioinformatic platform for multiomics analyses
The rapid developments of high‐throughput sequencing technology in the last decade
allowed the emergence of multiomics analyses. Analytic platforms for high‐throughput omics …
allowed the emergence of multiomics analyses. Analytic platforms for high‐throughput omics …