Neurological and immunological signals constitute an extensive regulatory network in our
body that maintains physiology and homeostasis. The cholinergic system plays a significant …

GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …

The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …

Binding of the neurotransmitter acetylcholine to its receptors on muscle fibers depolarizes
the membrane and thereby triggers muscle contraction. We sought to understand at the level …

During development, motor neurons originating in the brainstem and spinal cord form
elaborate synapses with skeletal muscle fibres. These neurons release acetylcholine (ACh) …

Fast synaptic communication requires receptors that respond to the presence of
neurotransmitter by opening an ion channel across the post-synaptic membrane. The …

Insecticides are indispensable tools for plant protection in modern agriculture. Despite
having highly heterogeneous structures, many neurotoxic insecticides use similar principles …

Bacterial spores resist antibiotics and sterilization and can remain metabolically inactive for
decades, but they can rapidly germinate and resume growth in response to nutrients …

Ligand-gated ion channels mediate signal transduction at chemical synapses and transition
between resting, open, and desensitized states in response to neurotransmitter binding …

Autoantibodies targeting neuronal membrane proteins can cause encephalitis, seizures,
and severe behavioral abnormalities. While antibodies for several neuronal targets have …