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Killer Ig-like receptors (KIRs): their role in NK cell modulation and developments leading to their clinical exploitation
Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …
control of tumor growth and metastasis spread. The discovery of HLA class I specific …
Major histocompatibility complex genomics and human disease
Over several decades, various forms of genomic analysis of the human major
histocompatibility complex (MHC) have been extremely successful in picking up many …
histocompatibility complex (MHC) have been extremely successful in picking up many …
Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry
Natural killer (NK) cells play critical roles in immune defense and reproduction, yet remain
the most poorly understood major lymphocyte population. Because their activation is …
the most poorly understood major lymphocyte population. Because their activation is …
Structure/function of human killer cell immunoglobulin‐like receptors: lessons from polymorphisms, evolution, crystal structures and mutations
KS Campbell, AK Purdy - Immunology, 2011 - Wiley Online Library
Stimulation or tolerance of natural killer (NK) cells is achieved through a cross‐talk of signals
derived from cell surface activating and inhibitory receptors. Killer cell immunoglobulin‐like …
derived from cell surface activating and inhibitory receptors. Killer cell immunoglobulin‐like …
Different Patterns of Evolution in the Centromeric and Telomeric Regions of Group A and B Haplotypes of the Human Killer Cell Ig-Like Receptor Locus
CW Pyo, LA Guethlein, Q Vu, R Wang, L Abi-Rached… - PloS one, 2010 - journals.plos.org
The fast evolving human KIR gene family encodes variable lymphocyte receptors specific for
polymorphic HLA class I determinants. Nucleotide sequences for 24 representative human …
polymorphic HLA class I determinants. Nucleotide sequences for 24 representative human …
Defining KIR and HLA class I genotypes at highest resolution via high-throughput sequencing
The physiological functions of natural killer (NK) cells in human immunity and reproduction
depend upon diverse interactions between killer cell immunoglobulin-like receptors (KIRs) …
depend upon diverse interactions between killer cell immunoglobulin-like receptors (KIRs) …
Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors
W Jiang, C Johnson, J Jayaraman, N Simecek… - Genome …, 2012 - genome.cshlp.org
The KIR complex appears to be evolving rapidly in humans, and more than 50 different
haplotypes have been described, ranging from four to 14 KIR loci. Previously it has been …
haplotypes have been described, ranging from four to 14 KIR loci. Previously it has been …
Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology
Killer‐cell immunoglobulin‐like receptors (KIR s) are components of two fundamental
biological systems essential for human health and survival. First, they contribute to host …
biological systems essential for human health and survival. First, they contribute to host …
Immunogenomics of killer cell immunoglobulin-like receptor (KIR) and HLA class I: coevolution and consequences for human health
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan …
Interactions between HLA class I molecules and killer-cell immunoglobulin-like receptors
(KIR) control natural killer cell (NK) functions in immunity and reproduction. Encoded by …
(KIR) control natural killer cell (NK) functions in immunity and reproduction. Encoded by …