Thinking points for effective batch correction on biomedical data

HWH Hui, W Kong, WWB Goh - Briefings in Bioinformatics, 2024 - academic.oup.com
Batch effects introduce significant variability into high-dimensional data, complicating
accurate analysis and leading to potentially misleading conclusions if not adequately …

[HTML][HTML] DeepResBat: deep residual batch harmonization accounting for covariate distribution differences

L An, C Zhang, N Wulan, S Zhang, P Chen, F Ji… - Medical Image …, 2025 - Elsevier
Pooling MRI data from multiple datasets requires harmonization to reduce undesired inter-
site variabilities, while preserving effects of biological variables (or covariates). The popular …

Pooling image datasets with multiple covariate shift and imbalance

SP Chytas, VS Lokhande, V Singh - The Twelfth International …, 2024 - openreview.net
Small sample sizes are common in many disciplines, which necessitates pooling roughly
similar datasets across multiple sites/institutions to study weak but relevant associations …

Healthy core: Harmonizing brain MRI for supporting multicenter migraine classification studies

H Yoon, TJ Schwedt, CD Chong, O Olatunde, T Wu - PloS one, 2024 - journals.plos.org
Multicenter and multi-scanner imaging studies may be necessary to ensure sufficiently large
sample sizes for develo** accurate predictive models. However, multicenter studies …

[HTML][HTML] When no answer is better than a wrong answer: A causal perspective on batch effects

EW Bridgeford, M Powell, G Kiar, S Noble… - Imaging …, 2025 - direct.mit.edu
Batch effects, undesirable sources of variability across multiple experiments, present
significant challenges for scientific and clinical discoveries. Batch effects can (i) produce …

DPABI harmonization: A toolbox for harmonizing multi-site brain imaging for big-data era

YW Wang, HL Wang, CG Yan - Imaging Neuroscience, 2024 - direct.mit.edu
Pooling multi-site datasets is the dominant trend to expand sample sizes in neuroimaging
field, thereby enhancing statistical power and reproducibility of research findings …

A Causal Perspective for Batch Effects: when is no answer better than a wrong answer?

EW Bridgeford, M Powell, G Kiar, S Noble, J Chung… - bioRxiv, 2021 - biorxiv.org
Batch effects, undesirable sources of variance across multiple experiments, present a
substantial hurdle for scientific and clinical discoveries. Specifically, the presence of batch …