Current Methods for the Characterization of O-Glycans

H Wilkinson, R Saldova - Journal of proteome research, 2020 - ACS Publications
Glycosylation is crucial in cellular metabolism and survival. Of interest is the role of N-linked
and O-linked glycans in disease states. Robust analytical methods must be defined to …

Contributions of mass spectrometry to peptide and protein structure

K Biemann - Biomedical & environmental mass spectrometry, 1988 - Wiley Online Library
With the advent of recombinant deoxyribonucleic acid (DNA) technology which allows a
wide range of manipulation of genes and their expression in cell lines other than the natural …

A single sulfatase is required to access colonic mucin by a gut bacterium

AS Luis, C **, GV Pereira, RWP Glowacki, SR Gugel… - Nature, 2021 - nature.com
Humans have co-evolved with a dense community of microbial symbionts that inhabit the
lower intestine. In the colon, secreted mucus creates a barrier that separates these …

A systematic nomenclature for carbohydrate fragmentations in FAB-MS/MS spectra of glycoconjugates

B Domon, CE Costello - Glycoconjugate journal, 1988 - Springer
A summary of the ion types observed in the Fast Atom Bombardment Mass Spectrometry
(FAB-MS) and collision induced decomposition (CID) MS/MS spectra of glycoconjugates …

Mass spectrometry of oligosaccharides

J Zaia - Mass spectrometry reviews, 2004 - Wiley Online Library
Abstract I. Introduction 162 II. CHARACTERISTICS OF TANDEM MASS SPECTRA OF
CARBOHYDRATES 163 A. Ionization of Carbohydrates 163 1. Electrospray Ionization (ESI) …

The SPPL3-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses

MLM Jongsma, AA de Waard, M Raaben, T Zhang… - Immunity, 2021 - cell.com
Summary HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens
to cognate CD8+ T cells. This process is often hijacked by tumors and pathogens for …

[HTML][HTML] Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics …

W Zheng, J Kollmeyer, H Symolon, A Momin… - … et Biophysica Acta (BBA …, 2006 - Elsevier
Sphingolipids are comprised of a backbone sphingoid base that may be phosphorylated,
acylated, glycosylated, bridged to various headgroups through phosphodiester linkages, or …

Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry

AH Merrill Jr, MC Sullards, JC Allegood, S Kelly… - Methods, 2005 - Elsevier
Sphingolipids are a highly diverse category of compounds that serve not only as
components of biologic structures but also as regulators of numerous cell functions …

The Putative Endoglucanase PcGH61D from Phanerochaete chrysosporium Is a Metal-Dependent Oxidative Enzyme that Cleaves Cellulose

B Westereng, T Ishida, G Vaaje-Kolstad, M Wu… - PloS one, 2011 - journals.plos.org
Many fungi growing on plant biomass produce proteins currently classified as glycoside
hydrolase family 61 (GH61), some of which are known to act synergistically with cellulases …

Mass spectrometry for structural characterization of therapeutic antibodies

Z Zhang, H Pan, X Chen - Mass spectrometry reviews, 2009 - Wiley Online Library
Antibodies, also known as immunoglobulins, have emerged as one of the most promising
classes of therapeutics in the biopharmaceutical industry. The need for complete …