Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …

The concept of cognitive impairment intervening between normal ageing and very early
dementia has been in the literature for many years. Recently, the construct of mild cognitive …

Background Subjects with a mild cognitive impairment (MCI) have a memory impairment
beyond that expected for age and education yet are not demented. These subjects are …

The field of aging and dementia is focusing on the characterization of the earliest stages of
cognitive impairment. Recent research has identified a transitional state between the …

The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …

Although dementia has been described in ancient texts over many centuries (eg,“Be kind to
your father, even if his mind fail him.”–Old Testament: Sirach 3: 12), our knowledge of its …

Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected
for an individual's age and education level but that does not interfere notably with activities …

Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

In the past 10 years, there has been a virtual explosion in the literature concerning the
construct of mild cognitive impairment. The interest in this topic demonstrates the increasing …

Background Mild cognitive impairment (MCI) is considered to be a transitional stage
between aging and Alzheimer disease (AD). Objective To determine whether MCI …