The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

This review highlights the biological importance of mitochondrial energy metabolism and the
applications of multiple optical/electrochemical approaches to determine energy …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

While it is generally accepted that mitochondrial reactive oxygen species (ROS) balance
depends on the both rate of single electron reduction of O2 to superoxide (O2−) by the …

The high renal oxygen (O2) demand is associated primarily with tubular O2 consumption
(Qo2) necessary for solute reabsorption. Increasing O2 delivery relative to demand via …

Multiple sclerosis (MS) represents the most common acquired demyelinating disorder of the
central nervous system (CNS). Its pathogenesis, in parallel with the well-established role of …

The role of oncoproteins and tumor suppressor proteins in promoting the malignant
transformation of mammalian cells by affecting properties such as proliferative signalling …

Cancer cells have an abnormally high mitochondrial membrane potential (ΔΨm), which is
associated with enhanced invasive properties in vitro and increased metastases in vivo. The …

Abstract Primary coenzyme Q 10 (CoQ 10) deficiency includes a group of rare autosomal
recessive disorders primarily characterized by neurological and muscular symptoms. Rarely …

Cardiac arrhythmias can cause sudden cardiac death (SCD) and add to the current heart
failure (HF) health crisis. Nevertheless, the pathological processes underlying arrhythmias …