The feed frame is a force-feeding device used in the die filling process. The die filling
process is crucial within pharmaceutical manufacturing to guarantee the critical quality …

In recent years, there has been increased focus on the calibration of discrete element
method (DEM) models to gain improved confidence in the simulation predictions. However …

Screw feeders are integrated as dispensing units in most continuous manufacturing
platforms. Hence, characterizing and modelling the residence time distribution (RTD) of …

Residence time distribution (RTD) modeling can aid the understanding and characterization
of macro-mixing in continuous powder processing unit operations by relating observed …

In continuous manufacturing (CM) of pharmaceutical tablets, the residence time distribution
(RTD) of the tablet press feed frame plays an important role in ensuring the critical quality …

The simulation of particles residence time distribution (RTD) in a gas-solid cyclone reactor
(GSCR) based on the CFD-DDPM tracer method was conducted. The comparison between …

Over the recent decade, benefits of continuous manufacturing (CM) of pharmaceutical
products have been acknowledged widely. In contrast to batch processes, the product is not …

This study focuses on the behavior of powder particles in a rotary tablet press with special
focus on the feed frame system. To obtain a better knowledge of the continuous …

The aim of the current study was to characterize the robustness of an integrated continuous
direct compression (CDC) line against disturbances from feeding, ie impulses of API and …

In this study, a concentration predicting soft sensor was achieved based on the Residence
Time Distribution (RTD) of an integrated, three-step pharmaceutical formulation line. The …