Adiponectin is an adipocyte-specific factor, first described in 1995. Over the past two
decades, numerous studies have elucidated the physiological functions of adiponectin in …

Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality
worldwide, posing a major threat on human health, productivity, and quality of life. Despite …

Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …

Hepatic gluconeogenesis is a main source of blood glucose during prolonged fasting and is
orchestrated by endocrine and neural pathways. Here we show that the hepatocyte-secreted …

Parallel to the increasing prevalence of obesity in the world, the mortality from
cardiovascular disease has also increased. Low-grade chronic inflammation in obesity …

Although mitophagy is known to restrict NLRP3 inflammasome activation, the underlying
regulatory mechanism remains poorly characterized. Here we describe a type of early …

The global epidemic of obesity is accompanied by an increased prevalence of
cardiovascular disease (CVD), in particular stroke and heart attack. Dysfunctional adipose …

Abstract p53 regulates several signaling pathways to maintain the metabolic homeostasis of
cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes …

Diabetes mellitus is a highly heterogeneous disorder encompassing several distinct forms
with different clinical manifestations including a wide spectrum of age at onset. Despite …

In the liver, insulin-mediated activation of the phosphatidylinositol 3-kinase (PI3K)/Akt
pathway is at the core of metabolic control. Multiple PI3K and Akt isoenzymes are found in …