Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …

Phase-separated biomolecular condensates exhibit a wide range of dynamic properties,
which depend on the sequences of the constituent proteins and RNAs. However, it is …

Conformational properties of intrinsically disordered proteins (IDPs) are governed by a
sequence-ensemble relationship. To differentiate the impact of sequence-local versus …

The cellular environment, characterized by its intricate composition and spatial organization,
hosts a variety of organelles, ranging from membrane-bound ones to membraneless …

Phase separation, crucial for spatially segregating biomolecules in cells, is well-understood
in the simple case of a few components with pairwise interactions. Yet, biological cells …

Under certain conditions, RNA repeat sequences phase separate, yielding protein-free
biomolecular condensates. Importantly, RNA repeat sequences have also been implicated …

The genome is traditionally divided into condensed heterochromatin and open euchromatin.
However, recent findings challenge this binary classification and the notion that chromatin …

Biomolecules composed of a limited set of chemical building blocks can colocalize into
distinct, spatially segregated compartments known as biomolecular condensates. While …

Cells contain multiple condensates which spontaneously form due to the heterotypic
interactions between their components. Although the proteins and disordered region …

We explore the reentrant condensation of polyelectrolytes triggered by multivalent salts,
whose phase-transition mechanism remains under debate. We propose a theory to study the …