[HTML][HTML] Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy

DH Upton, C Ung, SM George, M Tsoli, M Kavallaris… - Theranostics, 2022 - ncbi.nlm.nih.gov
Despite significant advances in research, the prognosis for both primary and secondary
brain cancers remains poor. The blood-brain barrier (BBB) is a complex and unique semi …

Progress in brain targeting drug delivery system by nasal route

AR Khan, M Liu, MW Khan, G Zhai - Journal of Controlled Release, 2017 - Elsevier
The blood–brain barrier (BBB) restricts the transport of potential therapeutic moieties to the
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …

Dissecting the molecular mechanism of apoptosis during photothermal therapy using gold nanoprisms

M Pérez-Hernández, P Del Pino, SG Mitchell… - ACS …, 2015 - ACS Publications
The photothermal response of plasmonic nanomaterials can be exploited for a number of
biomedical applications in diagnostics (biosensing and optoacoustic imaging) and therapy …

Tumor cell-derived extracellular vesicle-coated nanocarriers: an efficient theranostic platform for the cancer-specific delivery of anti-miR-21 and imaging agents

R JC Bose, S Uday Kumar, Y Zeng, R Afjei… - ACS …, 2018 - ACS Publications
MicroRNAs are critical regulators of cancer initiation, progression, and dissemination.
Extensive evidence suggests that the inhibition of over-expressed oncogenic miRNA …

Functionalized graphene oxide as a vehicle for targeted drug delivery and bioimaging applications

N Karki, H Tiwari, C Tewari, A Rana… - Journal of Materials …, 2020 - pubs.rsc.org
Graphene oxide (GO) has attracted tremendous attention as a most promising nanomaterial
among the carbon family since it emerged as a polynomial functional tool with rational …

Hyperthermia treatment advances for brain tumors

GP Skandalakis, DR Rivera, CD Rizea… - International Journal …, 2020 - Taylor & Francis
Hyperthermia therapy (HT) of cancer is a well-known treatment approach. With the advent of
new technologies, HT approaches are now important for the treatment of brain tumors. We …

Recent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicine

S Vial, RL Reis, JM Oliveira - Current Opinion in Solid State and Materials …, 2017 - Elsevier
Gold nanoparticles (AuNPs) have arisen a lot of interest in the clinical realms of
nanomedicine. Despite the large advances made in cancer research using AuNPs, their use …

Nano-therapies for glioblastoma treatment

E Alphandéry - Cancers, 2020 - mdpi.com
Traditional anti-cancer treatments are inefficient against glioblastoma, which remains one of
the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation …

Efficacy of temozolomide-conjugated gold nanoparticle photothermal therapy of drug-resistant glioblastoma and its mechanism study

Y Yu, A Wang, S Wang, Y Sun, L Chu… - Molecular …, 2022 - ACS Publications
Temozolomide (TMZ) is a standard-of-care chemotherapeutic drug for the treatment of
glioblastoma (GBM), but TMZ-acquired resistance limits its therapeutic effect. In this study …

Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma

J Verma, S Lal, CJF Van Noorden - International journal of …, 2014 - Taylor & Francis
Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary
brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and …