Simple Summary Antibody-drug conjugates (ADC) are a rapidly expanding class of anti-
cancer drugs, with twelve agents in current clinical use. Despite recent successes, many …

Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …

Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Pharmaceuticals have been developed for the treatment of a wide range of bone diseases
and disorders, but suffer from problematic delivery to the bone marrow. Neutrophils are …

Neutrophils are formidable defenders. Their vast numbers, constant production, high
cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently …

We integrated ubiquity, mass and lifespan of all major cell types to achieve a comprehensive
quantitative description of cellular turnover. We found a total cellular mass turnover of 80±20 …

Neutrophils have traditionally been viewed as bystanders or biomarkers of cardiovascular
disease. However, studies in the past decade have demonstrated the important functions of …

Neutrophils are recognized as an essential part of the innate immune response, but an
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …

Neutrophils are specialized innate cells that require constant replenishment from
proliferative bone marrow (BM) precursors as a result of their short half-life. Although it is …

The mononuclear phagocyte system comprises three types of cells: monocytes,
macrophages, and DCs, as well as their committed bone marrow progenitors (van Furth et …