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[HTML][HTML] The transmembrane protease TMPRSS2 as a therapeutic target for COVID-19 treatment
TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of
the respiratory and gastrointestinal tract, the prostate, and other organs. Although the …
the respiratory and gastrointestinal tract, the prostate, and other organs. Although the …
The immune response to COVID‐19: Does sex matter?
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has created unprecedented
challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …
challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …
Learning through a pandemic: the current state of knowledge on COVID-19 and cancer
The ongoing coronavirus disease 2019 (COVID-19) pandemic has left patients with current
or past history of cancer facing disparate consequences at every stage of the cancer …
or past history of cancer facing disparate consequences at every stage of the cancer …
Effect of androgen suppression on clinical outcomes in hospitalized men with COVID-19: the HITCH randomized clinical trial
NG Nickols, Z Mi, E DeMatt, K Biswas… - JAMA network …, 2022 - jamanetwork.com
Importance SARS-CoV-2 entry requires the TMPRSS2 cell surface protease. Antiandrogen
therapies reduce expression of TMPRSS2. Objective To determine if temporary androgen …
therapies reduce expression of TMPRSS2. Objective To determine if temporary androgen …
5-alpha reductase inhibitors use in prostatic disease and beyond
B Chislett, D Chen, ML Perera, E Chung… - Translational …, 2023 - pmc.ncbi.nlm.nih.gov
5-alpha reductase inhibitors (5-ARIs) are commonly used and widely available, with benefits
observed from their effect on androgen signalling. Their effect relies on the inhibition of the 5 …
observed from their effect on androgen signalling. Their effect relies on the inhibition of the 5 …
The adverse impact of COVID-19 on men's health
JM Dubin, NE Bennett, JA Halpern - Current Opinion in Urology, 2022 - journals.lww.com
COVID-19 is a highly pathogenic virus that exerts adverse effects upon the male
genitourinary system in myriad ways. The COVID-19 infection can impact serum …
genitourinary system in myriad ways. The COVID-19 infection can impact serum …
Neurological complications associated with Covid‐19; molecular mechanisms and therapeutic approaches
With the progression of investigations on the pathogenesis of severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), neurological complications have emerged as a …
syndrome coronavirus 2 (SARS‐CoV‐2), neurological complications have emerged as a …
Antiandrogens as therapies for COVID-19: a systematic review
M Cani, S Epistolio, G Dazio, M Modesti, G Salfi… - Cancers, 2024 - mdpi.com
Simple Summary The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic recently represented an unexpected global issue. Due to its rapid spread and …
pandemic recently represented an unexpected global issue. Due to its rapid spread and …
Evaluation of the durability of the immune humoral response to COVID-19 vaccines in patients with cancer undergoing treatment or who received a stem cell …
QJ Khan, CR Bivona, GA Martin, J Zhang, B Liu… - JAMA …, 2022 - jamanetwork.com
Importance The durability of the antibody response to COVID-19 vaccines in patients with
cancer undergoing treatment or who received a stem cell transplant is unknown and may be …
cancer undergoing treatment or who received a stem cell transplant is unknown and may be …
Identification of Comorbidities, Genomic Associations, and Molecular Mechanisms for COVID‐19 Using Bioinformatics Approaches
Several studies have been done to identify comorbidities of COVID‐19. In this work, we
developed an analytical bioinformatics framework to reveal COVID‐19 comorbidities, their …
developed an analytical bioinformatics framework to reveal COVID‐19 comorbidities, their …