[HTML][HTML] The transmembrane protease TMPRSS2 as a therapeutic target for COVID-19 treatment

L Wettstein, F Kirchhoff, J Münch - International Journal of Molecular …, 2022 - mdpi.com
TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of
the respiratory and gastrointestinal tract, the prostate, and other organs. Although the …

The immune response to COVID‐19: Does sex matter?

JQ Ho, MR Sepand, B Bigdelou, T Shekarian… - …, 2022 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has created unprecedented
challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …

Learning through a pandemic: the current state of knowledge on COVID-19 and cancer

A Elkrief, JT Wu, C Jani, KT Enriquez, M Glover… - Cancer …, 2022 - aacrjournals.org
The ongoing coronavirus disease 2019 (COVID-19) pandemic has left patients with current
or past history of cancer facing disparate consequences at every stage of the cancer …

Effect of androgen suppression on clinical outcomes in hospitalized men with COVID-19: the HITCH randomized clinical trial

NG Nickols, Z Mi, E DeMatt, K Biswas… - JAMA network …, 2022 - jamanetwork.com
Importance SARS-CoV-2 entry requires the TMPRSS2 cell surface protease. Antiandrogen
therapies reduce expression of TMPRSS2. Objective To determine if temporary androgen …

5-alpha reductase inhibitors use in prostatic disease and beyond

B Chislett, D Chen, ML Perera, E Chung… - Translational …, 2023 - pmc.ncbi.nlm.nih.gov
5-alpha reductase inhibitors (5-ARIs) are commonly used and widely available, with benefits
observed from their effect on androgen signalling. Their effect relies on the inhibition of the 5 …

The adverse impact of COVID-19 on men's health

JM Dubin, NE Bennett, JA Halpern - Current Opinion in Urology, 2022 - journals.lww.com
COVID-19 is a highly pathogenic virus that exerts adverse effects upon the male
genitourinary system in myriad ways. The COVID-19 infection can impact serum …

Neurological complications associated with Covid‐19; molecular mechanisms and therapeutic approaches

M Mahboubi Mehrabani, MS Karvandi… - Reviews in Medical …, 2022 - Wiley Online Library
With the progression of investigations on the pathogenesis of severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), neurological complications have emerged as a …

Antiandrogens as therapies for COVID-19: a systematic review

M Cani, S Epistolio, G Dazio, M Modesti, G Salfi… - Cancers, 2024 - mdpi.com
Simple Summary The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic recently represented an unexpected global issue. Due to its rapid spread and …

Evaluation of the durability of the immune humoral response to COVID-19 vaccines in patients with cancer undergoing treatment or who received a stem cell …

QJ Khan, CR Bivona, GA Martin, J Zhang, B Liu… - JAMA …, 2022 - jamanetwork.com
Importance The durability of the antibody response to COVID-19 vaccines in patients with
cancer undergoing treatment or who received a stem cell transplant is unknown and may be …

Identification of Comorbidities, Genomic Associations, and Molecular Mechanisms for COVID‐19 Using Bioinformatics Approaches

SBS Omit, S Akhter, HK Rana… - BioMed Research …, 2023 - Wiley Online Library
Several studies have been done to identify comorbidities of COVID‐19. In this work, we
developed an analytical bioinformatics framework to reveal COVID‐19 comorbidities, their …