Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the
malignancy, as the cancer stroma may prompt tumour relapse and therapeutic resistance …

Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlap** processes, as successfully metastasizing cells assume …

This ESMO Clinical Practice Guidelines provide updated state-of-the-art recommendations
on management of early breast cancer (diagnosis, treatment and follow-up), compiled by a …

Importance Cohort studies show better survival after breast-conserving surgery (BCS) with
postoperative radiotherapy (RT) than after mastectomy (Mx) without RT. It remains unclear …

Background Whole-breast irradiation after breast-conserving surgery for patients with early-
stage breast cancer decreases ipsilateral breast-tumour recurrence (IBTR), yielding …

Background There have been conflicting studies reporting on survival advantages between
breast-conserving surgery with radiotherapy (BCS) in comparison with mastectomy. Our aim …

Background Despite its common use in cancer treatment, radiotherapy has not yet entered
the era of precision medicine, and there have been no approaches to adjust dose based on …

Cancer cells can be conceived as “living organisms” interacting with cellular or non‐cellular
components in the host internal environment, not only the local tumor microenvironment but …

PURPOSE Breast-conserving therapy (BCT) is the preferred treatment for unifocal breast
cancer (BC). The oncologic safety of BCT for multiple ipsilateral breast cancer (MIBC) has …

Methods: A literature search was conducted in the PubMed, Embase, and Cochrane
databases to identify relevant literature. Keywords included “mastectomy,”“breast conserving …