Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Ubiquitination, a pivotal posttranslational modification of proteins, plays a fundamental role
in regulating protein stability. The dysregulation of ubiquitinating and deubiquitinating …

More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …

Cancer is a global issue majorly affecting develo** countries. According to a survey, 63%
of deaths due to cancer are reported from develo** countries. There are different …

Ubiquitylation is a reversible protein modification that is implicated in many cellular
functions. Recently, much progress has been made in the characterization of a superfamily …

Deubiquitinating enzymes (DUBs) are proteases that process ubiquitin or ubiquitin-like gene
products, reverse the modification of proteins by a single ubiquitin (-like) protein, and …

The ubiquitin proteasome system (UPS) is the main system for controlled protein
degradation and a key regulator of fundamental cellular processes. The dependency of …

Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability
to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at …

Deubiquitinating enzymes, or DUBs, comprise a family of proteases that regulate
ubiquitination dynamics. Since their discovery, genetic and functional studies have …

Proteases have an important role in many signalling pathways, and represent potential drug
targets for diseases ranging from cardiovascular disorders to cancer, as well as for …