Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …

Microglia are the CNS resident immune cells that react to misfolded proteins through pattern
recognition receptor ligation and activation of inflammatory pathways. Here, we studied how …

Damaged mitochondria need to be cleared to maintain the quality of the mitochondrial pool.
Here, we report mitocytosis, a migrasome-mediated mitochondrial quality-control process …

Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of
the beating heart. It is unclear whether these cells, which are long-lived and rarely renew …

Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …

Mitochondria are central hubs of cellular metabolism and are tightly connected to signaling
pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other …

Senescence is a cellular state linked to ageing and age-onset disease across many
mammalian species,. Acutely, senescent cells promote wound healing, and prevent tumour …