Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

A key hallmark of Parkinson's disease (PD) is Lewy pathology. Composed of α-synuclein,
Lewy pathology is found both in dopaminergic neurons that modulate motor function, and …

The development of interventions to slow or halt the progression of Parkinson's disease
remains a priority for patients and researchers alike. To date, no agents have been shown to …

Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …

Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …

Accumulation of neuronal α-synuclein is a prominent feature in Parkinson's disease. More
recently, such abnormal protein aggregation has been reported to spread from cell to cell …

That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could
spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α …