Biology and models of the blood–brain barrier
The blood–brain barrier (BBB) is one of the most selective endothelial barriers. An
understanding of its cellular, morphological, and biological properties in health and disease …
understanding of its cellular, morphological, and biological properties in health and disease …
Emerging application of nanorobotics and artificial intelligence to cross the BBB: advances in design, controlled maneuvering, and targeting of the barriers
The blood–brain barrier (BBB) is a prime focus for clinicians to maintain the homeostatic
function in health and deliver the theranostics in brain cancer and number of neurological …
function in health and deliver the theranostics in brain cancer and number of neurological …
The choroid plexus: a missing link in our understanding of brain development and function
NR Saunders, KM Dziegielewska… - Physiological …, 2023 - journals.physiology.org
Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier,
despite a much longer history. This review has two overall aims. The first is to outline long …
despite a much longer history. This review has two overall aims. The first is to outline long …
In vitro blood brain barrier models: An overview
Understanding the composition and function of the blood brain barrier (BBB) enables the
development of novel, innovative techniques for administering central nervous system …
development of novel, innovative techniques for administering central nervous system …
Micropatterned neurovascular interface to mimic the blood–brain barrier's neurophysiology and micromechanical function: a BBB-on-CHIP model
A hybrid blood–brain barrier (BBB)-on-chip cell culture device is proposed in this study by
integrating microcontact printing and perfusion co-culture to facilitate the study of BBB …
integrating microcontact printing and perfusion co-culture to facilitate the study of BBB …
Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders
F Fanizza, M Campanile, G Forloni… - Journal of Tissue …, 2022 - journals.sagepub.com
The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs
development pipeline by mimicking the physiological environment and functions of human …
development pipeline by mimicking the physiological environment and functions of human …
Evolving new-age strategies to transport therapeutics across the blood-brain-barrier
A basic understanding of the blood–brain barrier (BBB) is essential for the novel
advancements in targeting drugs specific to the brain. Neoplasm compromising the internal …
advancements in targeting drugs specific to the brain. Neoplasm compromising the internal …
Blood-brain barrier models: Rationale for selection
AS Hanafy, D Dietrich, G Fricker… - Advanced Drug Delivery …, 2021 - Elsevier
Brain delivery is a broad research area, the outcomes of which are far hindered by the
limited permeability of the blood–brain barrier (BBB). Over the last century, research has …
limited permeability of the blood–brain barrier (BBB). Over the last century, research has …
Blood–Brain Barrier Breakdown in Neuroinflammation: Current In Vitro Models
S Brandl, M Reindl - International Journal of Molecular Sciences, 2023 - mdpi.com
The blood–brain barrier, which is formed by tightly interconnected microvascular endothelial
cells, separates the brain from the peripheral circulation. Together with other central nervous …
cells, separates the brain from the peripheral circulation. Together with other central nervous …
Continuous Monitoring Reveals Protective Effects of N‐Acetylcysteine Amide on an Isogenic Microphysiological Model of the Neurovascular Unit
Microphysiological systems mimic the in vivo cellular ensemble and microenvironment with
the goal of providing more human‐like models for biopharmaceutical research. In this study …
the goal of providing more human‐like models for biopharmaceutical research. In this study …