Obesity-induced neuroinflammation: beyond the hypothalamus
Obesity is now a worldwide health issue. Far from being limited to weight gain, obesity is
generally associated with low-grade inflammation and with a cluster of disorders collectively …
generally associated with low-grade inflammation and with a cluster of disorders collectively …
Mitochondria as central regulators of neural stem cell fate and cognitive function
Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …
Brain insulin resistance and hippocampal plasticity: mechanisms and biomarkers of cognitive decline
In the last decade, much attention has been devoted to the effects of nutrient-related signals
on brain development and cognitive functions. A turning point was the discovery that brain …
on brain development and cognitive functions. A turning point was the discovery that brain …
Hippocampal insulin resistance and cognitive dysfunction
Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …
Interplay between the gut-brain axis, obesity and cognitive function
A Agustí, MP García-Pardo, I López-Almela… - Frontiers in …, 2018 - frontiersin.org
Obesity continues to be one of the major public health problems due to its high prevalence
and co-morbidities. Common co-morbidities not only include cardiometabolic disorders but …
and co-morbidities. Common co-morbidities not only include cardiometabolic disorders but …
[HTML][HTML] Diet, inflammation and the gut microbiome: mechanisms for obesity-associated cognitive impairment
Poor diet and obesity are associated with cognitive impairment throughout adulthood, and
increased dementia risk in aging. Here we review the current literature interrogating the …
increased dementia risk in aging. Here we review the current literature interrogating the …
High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice
Insulin resistance and other features of the metabolic syndrome are increasingly recognized
for their effects on cognitive health. To ascertain mechanisms by which this occurs, we fed …
for their effects on cognitive health. To ascertain mechanisms by which this occurs, we fed …
Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats
C Boitard, A Cavaroc, J Sauvant, A Aubert… - Brain, behavior, and …, 2014 - Elsevier
In addition to metabolic and cardiovascular disorders, obesity pandemic is associated with
chronic low-grade inflammation as well as adverse cognitive outcomes. However, the …
chronic low-grade inflammation as well as adverse cognitive outcomes. However, the …
Perineuronal nets: plasticity, protection, and therapeutic potential
The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …
BDNF effects on dendritic spine morphology and hippocampal function
O von Bohlen und Halbach… - Cell and tissue …, 2018 - Springer
Neurotrophins, including brain-derived neurotrophic factor (BDNF), are expressed in the
hippocampus, as well as their precursors, the pro-neurotrophins. The neurotrophins signal …
hippocampus, as well as their precursors, the pro-neurotrophins. The neurotrophins signal …