Alternatives to animal models and their application in the discovery of species susceptibility to SARS-CoV-2 and other respiratory infectious pathogens: A review

S Runft, I Faerber, J Krueger, N Krueger… - Veterinary …, 2022 - journals.sagepub.com
The emergence of the coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) inspired rapid research efforts targeting …

H5N1 clade 2.3. 4.4 b avian influenza viruses replicate in differentiated bovine airway epithelial cells cultured at air-liquid interface

L Bordes, NM Gerhards, S Peters… - Journal of General …, 2024 - microbiologyresearch.org
Highly pathogenic avian influenza (HPAI) H5N1 viruses are responsible for disease
outbreaks in wild birds and poultry, resulting in devastating losses to the poultry sector …

Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV across mammals

M Li, J Du, W Liu, Z Li, F Lv, C Hu, Y Dai… - The ISME …, 2023 - academic.oup.com
Exploring wild reservoirs of pathogenic viruses is critical for their long-term control and for
predicting future pandemic scenarios. Here, a comparative in vitro infection analysis was first …

The upper respiratory tract of felids is highly susceptible to SARS-CoV-2 infection

N Krüger, C Rocha, S Runft, J Krüger, I Färber… - International journal of …, 2021 - mdpi.com
Natural or experimental infection of domestic cats and virus transmission from humans to
captive predatory cats suggest that felids are highly susceptible to SARS-CoV-2 infection …

Resistance to SARS-CoV-2 infection in camelid nasal organoids is associated with lack of ACE2 expression

TI Breugem, S Riesebosch, D Schipper, AZ Mykytyn… - npj Viruses, 2024 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects a variety of
animal species. Susceptibility to SARS-CoV-2 is primarily determined by the utilization of the …

Recurrent viral capture of cellular phosphodiesterases that antagonize OAS-RNase L

SA Goldstein, NC Elde - Proceedings of the National …, 2024 - National Acad Sciences
Phosphodiesterases (PDEs) encoded by viruses are putatively acquired by horizontal
transfer of cellular PDE ancestor genes. Viral PDEs inhibit the OAS-RNase L antiviral …

Time-resolved characterization of the innate immune response in the respiratory epithelium of human, porcine, and bovine during influenza virus infection

L Laloli, MF Licheri, L Probst, M Licheri… - Frontiers in …, 2022 - frontiersin.org
Viral cross-species transmission is recognized to be a major threat to both human and
animal health, however detailed information on determinants underlying virus host tropism …

Equine bronchial epithelial cells are susceptible to cell entry with a SARS-CoV-2 pseudovirus but reveal low replication efficiency

RM Legere, AR Allegro, Y Affram… - American Journal of …, 2023 - Am Vet Med Assoc
OBJECTIVE To examine the susceptibility of cultured primary equine bronchial epithelial
cells (EBECs) to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

In Vitro Characteristics of Canine Primary Tracheal Epithelial Cells Maintained at an Air–Liquid Interface Compared to In Vivo Morphology

S Runft, I Färber, J Krüger, K Schöne… - International Journal of …, 2023 - mdpi.com
Culturing respiratory epithelial cells at an air–liquid interface (ALI) represents an established
method for studies on infection or toxicology by the generation of an in vivo-like respiratory …

Recurrent Viral Capture of a Host-Derived Immune Antagonist

SA Goldstein, NC Elde - bioRxiv, 2023 - biorxiv.org
Phosphodiesterases (PDEs) encoded by nidoviruses and rotaviruses (RVs) promote viral
replication and pathogenesis. Putatively acquired by horizontal transfer of cellular PDE …