NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology

A Vermot, I Petit-Härtlein, SME Smith, F Fieschi - Antioxidants, 2021 - mdpi.com
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

β2 Integrins—multi-functional leukocyte receptors in health and disease

M Bednarczyk, H Stege, S Grabbe, M Bros - International journal of …, 2020 - mdpi.com
β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Targeting tumor-stromal interactions in pancreatic cancer: impact of collagens and mechanical traits

P Maneshi, J Mason, M Dongre… - Frontiers in Cell and …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst outcomes among cancers
with a 5-years survival rate of below 10%. This is a result of late diagnosis and the lack of …

[HTML][HTML] The Role of Bovine Milk-Derived Exosomes in Human Health and Disease

M Jabłońska, T Sawicki, J Żulewska, K Staniewska… - Molecules, 2024 - mdpi.com
Bovine milk is widely recognized as one of the most valuable sources of nutrients such as
proteins, fats, vitamins, and minerals that support the development and health of the body. In …

Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging

P Kordowitzki, A Haghani, JA Zoller, CZ Li, K Raj… - Aging cell, 2021 - Wiley Online Library
Cattle are an attractive animal model of fertility in women due to their high degree of
similarity relative to follicle selection, embryo cleavage, blastocyst formation, and gestation …

The regulation of shrimp metabolism by the white spot syndrome virus (WSSV)

R Kumar, JY Huang, YS Ng, CY Chen… - Reviews in …, 2022 - Wiley Online Library
For more than three decades, infectious diseases have been one of the major causes of
economic losses in the global shrimp industry. One of the deadliest of the shrimp pathogens …

Cepharanthine suppresses herpes simplex virus type 1 replication through the downregulation of the PI3K/Akt and p38 MAPK signaling pathways

Y Liu, L Chen, W Liu, D Li, J Zeng, Q Tang… - Frontiers in …, 2021 - frontiersin.org
Cepharanthine (CEP) is a naturally occurring isoquinoline alkaloid extracted from Stephania
cepharantha Hayata. Although its underlying molecular mechanism is not fully understood …

Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin

N Gao, A Raduka, F Rezaee - Journal of Cell Science, 2022 - journals.biologists.com
Respiratory syncytial virus (RSV) infection is the leading cause of acute lower respiratory
tract infection in young children worldwide. Our group recently revealed that RSV infection …

Inhibition of extracellular vesicle biogenesis in tumor cells: A possible way to reduce tumorigenesis

J Rezaie, A Akbari… - Cell Biochemistry and …, 2022 - Wiley Online Library
Most eukaryotic cells secrete extracellular vesicles (EVs), which contribute to intracellular
communication through transferring different biomolecules such as proteins, RNAs, and …

Systematic elucidation of the mechanism of quercetin against gastric cancer via network pharmacology approach

L Yang, Z Hu, J Zhu, Q Liang, H Zhou… - BioMed research …, 2020 - Wiley Online Library
This study was aimed at elucidating the potential mechanisms of quercetin in the treatment
of gastric cancer (GC). A network pharmacology approach was used to analyze the targets …