Lipids in the brain are major components playing structural functions as well as
physiological roles in nerve cells, such as neural communication, neurogenesis, synaptic …

Simple sphingolipids such as ceramide and sphingomyelin (SM) as well as more complex
glycosphingolipids play very important roles in cell function under physiological conditions …

Heterozygous mutations in GBA1, the gene encoding lysosomal glucocerebrosidase, are
the most frequent known genetic risk factor for Parkinson's disease. Reduced …

Sphingomyelin constitutes membrane microdomains such as lipid raft, caveolae, and
clathrin-coated pits and implicates in the regulation of trans-membrane signaling. On the …

Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in
cholesterol and sphingolipids. They represent a platform for protein-lipid and protein–protein …

Acid ceramidase (ACDase) deficiency is a spectrum of disorders that includes a rare
lysosomal storage disorder called Farber disease (FD) and a rare epileptic disorder called …

Lipid droplets (LDs) and lysosomes, as the important subcellular organelles, play vital roles
in cell metabolism and physiology. The finding that LDs can be degraded by lysosomes …

Lysosomal polarity affects the interaction activities between enzymes and substrates at the
cellular level. Abnormal lysosomal polarity closely linked with disorders and diseases is …

Lipids have many important yet distinct functions in cellular homeostasis such as forming an
impermeable barrier separating intracellular and extracellular compartments, providing a …

An essential sulfhydryl amino acid in the human body is cysteine (Cys). Its abnormal level is
related to coronary heart disease, hypertension, growth retardation, sleepiness, liver injury …