The NF1 somatic mutational landscape in sporadic human cancers
C Philpott, H Tovell, IM Frayling, DN Cooper… - Human genomics, 2017 - Springer
Abstract Background Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man
(OMIM)# 162200) is an autosomal dominantly inherited tumour predisposition syndrome …
(OMIM)# 162200) is an autosomal dominantly inherited tumour predisposition syndrome …
CD117/c-kit in cancer stem cell-mediated progression and therapeutic resistance
Metastasis is the primary cause of cancer patient morbidity and mortality, but due to
persisting gaps in our knowledge, it remains untreatable. Metastases often occur as patient …
persisting gaps in our knowledge, it remains untreatable. Metastases often occur as patient …
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers
BACKGROUND. Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …
Genomics of lethal prostate cancer at diagnosis and castration resistance
The genomics of primary prostate cancer differ from those of metastatic castration-resistant
prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer …
prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer …
[HTML][HTML] Institutional implementation of clinical tumor profiling on an unselected cancer population
BACKGROUND. Comprehensive genomic profiling of a patient's cancer can be used to
diagnose, monitor, and recommend treatment. Clinical implementation of tumor profiling in …
diagnose, monitor, and recommend treatment. Clinical implementation of tumor profiling in …
[HTML][HTML] Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma
PJ Siska, KE Beckermann, FM Mason, G Andrejeva… - JCI insight, 2017 - ncbi.nlm.nih.gov
Cancer cells can inhibit effector T cells (Teff) through both immunomodulatory receptors and
the impact of cancer metabolism on the tumor microenvironment. Indeed, Teff require high …
the impact of cancer metabolism on the tumor microenvironment. Indeed, Teff require high …
MEXPRESS: visualizing expression, DNA methylation and clinical TCGA data
Background In recent years, increasing amounts of genomic and clinical cancer data have
become publically available through large-scale collaborative projects such as The Cancer …
become publically available through large-scale collaborative projects such as The Cancer …
Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has traditionally been thought of as an
immunologically quiescent tumor type presumably because of a relatively low tumor …
immunologically quiescent tumor type presumably because of a relatively low tumor …
Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes
Background Epithelial ovarian cancer (OC) is a heterogenous disease consisting of five
major histologically distinct subtypes: high-grade serous (HGSOC), low-grade serous …
major histologically distinct subtypes: high-grade serous (HGSOC), low-grade serous …
Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma
BACKGROUND Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary
glands and other sites, characterized by high rates of relapse and distant spread …
glands and other sites, characterized by high rates of relapse and distant spread …