Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Mechanotransduction couples mechanical stimulation with ion flux, which is critical for
normal biological processes involved in neuronal cell development, pain sensation, and red …

The mechanically activated Piezo channel plays a versatile role in conferring
mechanosensitivity to various cell types. However, how it incorporates its intrinsic …

The cardiovascular system provides blood supply throughout the body and as such is
perpetually applying mechanical forces to cells and tissues. Thus, this system is primed with …

Mechanical forces are fundamental in cardiovascular biology, and deciphering the
mechanisms by which they act remains a testing frontier in cardiovascular research. Here …

The evolutionarily conserved Piezo channel family, including Piezo1 and Piezo2 in
mammals, serves as versatile mechanotransducers in various cell types and consequently …

Piezo channels are critical cellular sensors of mechanical forces. Despite their large size,
ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological …

Mechanosensitive ion channels rely on membrane composition to transduce physical stimuli
into electrical signals. The Piezo1 channel mediates mechanoelectrical transduction and …

Mechanotransduction has a key role in vascular development, physiology, and disease
states. Piezo1 is a mechanosensitive (MS) nonselective cationic channel that occurs in …