B cells, plasma cells and antibody repertoires in the tumour microenvironment
Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in sha** antitumour immune responses. In tumour …
lymph nodes can have important roles in sha** antitumour immune responses. In tumour …
Current and future influenza vaccines
S Yamayoshi, Y Kawaoka - Nature medicine, 2019 - nature.com
Although antiviral drugs and vaccines have reduced the economic and healthcare burdens
of influenza, influenza epidemics continue to take a toll. Over the past decade, research on …
of influenza, influenza epidemics continue to take a toll. Over the past decade, research on …
[HTML][HTML] Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses
Vaccines generate high-affinity antibodies by recruiting antigen-specific B cells to germinal
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
Immune history and influenza virus susceptibility
S Cobey, SE Hensley - Current opinion in virology, 2017 - Elsevier
Highlights•Early viral infections shape B cell response recalled against future viral
strains.•Competition between memory and naïve B cells occurs in secondary viral …
strains.•Competition between memory and naïve B cells occurs in secondary viral …
Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation
In this study, we report that antigen-specific CD19+ CD27+ CD21lo (CD21lo) B cells are
transiently induced 14 to 28 days after immunization, at the time germinal centers (GCs) …
transiently induced 14 to 28 days after immunization, at the time germinal centers (GCs) …
Practical guidelines for B-cell receptor repertoire sequencing analysis
High-throughput sequencing of B-cell immunoglobulin repertoires is increasingly being
applied to gain insights into the adaptive immune response in healthy individuals and in …
applied to gain insights into the adaptive immune response in healthy individuals and in …
Bioinformatic and statistical analysis of adaptive immune repertoires
High-throughput sequencing (HTS) of immune repertoires has enabled the quantitative
analysis of adaptive immune responses and offers the potential to revolutionize research in …
analysis of adaptive immune responses and offers the potential to revolutionize research in …
High-quality full-length immunoglobulin profiling with unique molecular barcoding
MA Turchaninova, A Davydov, OV Britanova… - Nature protocols, 2016 - nature.com
High-throughput sequencing analysis of hypermutating immunoglobulin (IG) repertoires
remains a challenging task. Here we present a robust protocol for the full-length profiling of …
remains a challenging task. Here we present a robust protocol for the full-length profiling of …
Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles
Individual variation in germline and expressed B-cell immunoglobulin (Ig) repertoires has
been associated with aging, disease susceptibility, and differential response to infection and …
been associated with aging, disease susceptibility, and differential response to infection and …
Activation dynamics and immunoglobulin evolution of pre-existing and newly generated human memory B cell responses to influenza hemagglutinin
Vaccine-induced memory B cell responses to evolving viruses like influenza A involve
activation of pre-existing immunity and generation of new responses. To define the …
activation of pre-existing immunity and generation of new responses. To define the …