Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

Piezo proteins have recently been identified as ion channels mediating mechanosensory
transduction in mammalian cells. Characterization of these channels has yielded important …

Pain information processing in the spinal cord has been postulated to rely on nociceptive
transmission (T) neurons receiving inputs from nociceptors and Aβ mechanoreceptors, with …

The sense of touch is fundamental as it provides vital, moment-to-moment information about
the nature of our physical environment. Primary sensory neurons provide the basis for this …

Central sensitization is a physiological mechanism associated with enhanced sensitivity and
pain responses. At present, central sensitization cannot be determined directly in humans …

Tactile and spontaneous pains are poorly managed symptoms of inflammatory and
neuropathic injury. Here, we found that transient receptor potential canonical 5 (TRPC5) is a …

Sensing force is crucial to maintain the viability of all living cells. Despite its fundamental
importance, how force is sensed at the molecular level remains largely unknown. Here we …

Trigeminal nerve injury is one of the causes of chronic orofacial pain. Patients suffering from
this condition have a significantly reduced quality of life. The currently available …

Etiological and clinical heterogeneity of small fiber neuropathy (SFN) precludes a unifying
approach and necessitates reliance on recognizable clinical syndromes. Symptoms of SFN …

Purpose There is growing evidence that vertebral column function and dysfunction play a
vital role in neuromuscular control. This invited review summarises the evidence about how …