Single-cell omics assays allow the identification of the type, subtype and functional state of a
single cell. To put such single-cell data in the context of tissues, spatially resolved omics can …

Aldehydes are widespread in the environment, with multiple sources such as food and
beverages, industrial effluents, cigarette smoke, and additives. The toxic effects of exposure …

Chromosomal instability (CIN) is common in solid tumours and fuels evolutionary adaptation
and poor prognosis by increasing intratumour heterogeneity. Systematic characterization of …

Inverted duplications, also known as foldback inversions, are commonly observed in
cancers and are the major class of chromosome rearrangement recovered from yeast cells …

Simple Summary The experimental/pathological observation of genome chaos (including
massive and large-scale translocations, chromothripsis, and polyploidy cancer cells) …

FANCM is a multifunctional DNA repair enzyme that acts as a sensor and coordinator of
replication stress responses, especially interstrand crosslink (ICL) repair mediated by the …

Neuroblastoma is a pediatric solid tumor characterized by strong clinical heterogeneity.
Although clinical risk-defining genomic alterations exist in neuroblastomas, the mutational …

Acute myeloid leukemia (AML) with TP53 mutation is one of the most lethal cancers and
portends an extremely poor prognosis. Based on in silico analyses of druggable genes and …

More than half of all patients with cancer receive radiation therapy, but resistance is
commonly observed. Currently, it is unknown whether resistance to radiation therapy is …

Alterations in DNA damage response (DDR) and related genes are present in up to 25% of
advanced prostate cancers (PCa). Most frequently altered genes are involved in the …