Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes
G Nygaard, GS Firestein - Nature Reviews Rheumatology, 2020 - nature.com
Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …
[HTML][HTML] Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective
Bioinformatic analysis of large and complex omics datasets has become increasingly useful
in modern day biology by providing a great depth of information, with its application to …
in modern day biology by providing a great depth of information, with its application to …
Systems bioinformatics: increasing precision of computational diagnostics and therapeutics through network-based approaches
Abstract Systems Bioinformatics is a relatively new approach, which lies in the intersection of
systems biology and classical bioinformatics. It focuses on integrating information across …
systems biology and classical bioinformatics. It focuses on integrating information across …
Scoring personalized molecular portraits identify systemic lupus erythematosus subtypes and predict individualized drug responses, symptomatology and disease …
Abstract Objectives Systemic Lupus Erythematosus is a complex autoimmune disease that
leads to significant worsening of quality of life and mortality. Flares appear unpredictably …
leads to significant worsening of quality of life and mortality. Flares appear unpredictably …
Machine learning reveals distinct gene signature profiles in lesional and nonlesional regions of inflammatory skin diseases
Analysis of gene expression from cutaneous lupus erythematosus, psoriasis, atopic
dermatitis, and systemic sclerosis using gene set variation analysis (GSVA) revealed that …
dermatitis, and systemic sclerosis using gene set variation analysis (GSVA) revealed that …
AutoCore: A network-based definition of the core module of human autoimmunity and autoinflammation
Although research on rare autoimmune and autoinflammatory diseases has enabled
definition of nonredundant regulators of homeostasis in human immunity, because of the …
definition of nonredundant regulators of homeostasis in human immunity, because of the …
An integrative approach for building personalized gene regulatory networks for precision medicine
Only a small fraction of patients respond to the drug prescribed to treat their disease, which
means that most are at risk of unnecessary exposure to side effects through ineffective …
means that most are at risk of unnecessary exposure to side effects through ineffective …
Transcriptional profiles of adjuvanted hepatitis B vaccines display variable interindividual homogeneity but a shared core signature
L De Mot, V Bechtold, V Bol, A Callegaro… - Science translational …, 2020 - science.org
The current routine use of adjuvants in human vaccines provides a strong incentive to
increase our understanding of how adjuvants differ in their ability to stimulate innate …
increase our understanding of how adjuvants differ in their ability to stimulate innate …
Prioritizing network communities
Uncovering modular structure in networks is fundamental for systems in biology, physics,
and engineering. Community detection identifies candidate modules as hypotheses, which …
and engineering. Community detection identifies candidate modules as hypotheses, which …
scDrugPrio: A framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
Background Ineffective drug treatment is a major problem for many patients with immune-
mediated inflammatory diseases (IMIDs). Important reasons are the lack of systematic …
mediated inflammatory diseases (IMIDs). Important reasons are the lack of systematic …