Shifting from chemical to biotechnological processes is one of the cornerstones of 21st
century industry. The production of a great range of chemicals via biotechnological means is …

With the advent of modern biotechnology, microorganisms from diverse lineages have been
used to produce bio-based feedstocks and bioactive compounds. Many of these compounds …

Diatoms are prominent marine microalgae, interesting not only from an ecological point of
view, but also for their possible use in biotechnology applications. They can be cultivated in …

Computational modelling of metabolic networks has become an established procedure in
the metabolic engineering of production strains. One key principle that is frequently used to …

Diatoms are eukaryotic microalgae that contain genes from various sources, including
bacteria and the secondary endosymbiotic host. Due to this unique combination of genes …

Elementary flux modes (EFMs) emerged as a formal concept to describe metabolic
pathways and have become an established tool for constraint-based modeling and …

Enforcing obligate coupling of growth with synthesis of a desired product has become a key
principle for metabolic engineering of microbial production strains. Various methods from …

Abstract Background Nannochloropsis salina (= Eustigmatophyceae) is a marine microalga
which has become a biotechnological target because of its high capacity to produce …

Elementary flux modes (EFMs) are non-decomposable steady-state pathways in metabolic
networks. They characterize phenotypes, quantify robustness or identify engineering targets …

Cancer cells are known to express the Warburg effect—increased glycolysis and formation
of lactic acid even in the presence of oxygen—as well as high glutamine uptake. In tumors …