Two-photon microscopy, combined with the appropriate optical labelling, enables the
measurement and tracking of submicrometer structures within brain cells, as well as the …

Though many folded proteins assume one stable structure that performs one function, a
small‐but‐increasing number remodel their secondary and tertiary structures and change …

Abstract l-Lactate is increasingly appreciated as a key metabolite and signaling molecule in
mammals. However, investigations of the inter-and intra-cellular dynamics of l-lactate are …

Due to the size and opacity of vertebrate brains, it has until now been impossible to
simultaneously record neuronal activity at cellular resolution across the entire adult brain. As …

Spontaneous activity refines neural connectivity prior to the onset of sensory experience, but
it remains unclear how such activity instructs axonal connectivity with subcellular precision …

Homeostatic plasticity (HP) encompasses a suite of compensatory physiological processes
that counteract neuronal perturbations, enabling brain resilience. Currently, we lack a …

Perceiving substrate-borne vibrations is a fundamental component of tactile perception. How
location (somatotopy) and frequency tuning (tonotopy) of vibrations are integratively …

During learning, synaptic connections between excitatory neurons in the brain display
considerable dynamism, with new connections being added and old connections …

Brain organoids are widely used to model brain development and diseases. However, a
major challenge in their application is the insufficient supply of oxygen and nutrients to the …

To determine how neuronal circuits encode and drive behavior, it is often necessary to
measure and manipulate different aspects of neurochemical signaling in awake animals …