Artificial intelligence to deep learning: machine intelligence approach for drug discovery
Drug designing and development is an important area of research for pharmaceutical
companies and chemical scientists. However, low efficacy, off-target delivery, time …
companies and chemical scientists. However, low efficacy, off-target delivery, time …
A global review on short peptides: frontiers and perspectives
Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …
entities via all domains of life and interfere with protein-protein interactions, which are …
Simulating 500 million years of evolution with a language model
More than three billion years of evolution have produced an image of biology encoded into
the space of natural proteins. Here we show that language models trained at scale on …
the space of natural proteins. Here we show that language models trained at scale on …
Evolutionary-scale prediction of atomic-level protein structure with a language model
Recent advances in machine learning have leveraged evolutionary information in multiple
sequence alignments to predict protein structure. We demonstrate direct inference of full …
sequence alignments to predict protein structure. We demonstrate direct inference of full …
DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks
J Hallgren, KD Tsirigos, MD Pedersen… - BioRxiv, 2022 - biorxiv.org
Transmembrane proteins span the lipid bilayer and are divided into two major structural
classes, namely alpha helical and beta barrels. We introduce DeepTMHMM, a deep …
classes, namely alpha helical and beta barrels. We introduce DeepTMHMM, a deep …
RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental …
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB), the US data center for the global PDB archive and a founding member of the …
PDB), the US data center for the global PDB archive and a founding member of the …
PubChem in 2021: new data content and improved web interfaces
Abstract PubChem (https://pubchem. ncbi. nlm. nih. gov) is a popular chemical information
resource that serves the scientific community as well as the general public, with millions of …
resource that serves the scientific community as well as the general public, with millions of …
BRENDA, the ELIXIR core data resource in 2021: new developments and updates
The BRENDA enzyme database (https://www. brenda-enzymes. org), established in 1987,
has evolved into the main collection of functional enzyme and metabolism data. In 2018 …
has evolved into the main collection of functional enzyme and metabolism data. In 2018 …
[PDF][PDF] Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods
to determine three-dimensional macromolecular structures, which are required to …
to determine three-dimensional macromolecular structures, which are required to …
The implications of IDH mutations for cancer development and therapy
Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …