Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Biogeography is the study of species distribution and diversity within an ecosystem and is at
the core of how we understand ecosystem dynamics and interactions at the macroscale. In …

While gut microbiome and host gene regulation independently contribute to gastrointestinal
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …

It is estimated that in the future, the number of new cancer cases worldwide will exceed the
19.3 million recorded in 2020, and the number of deaths will exceed 10 million. Cancer …

Researchers have discovered associations between elements of the intestinal microbiome
(including specific microbes, signaling pathways, and microbiota-related metabolites) and …

Gut microbiota dysbiosis is closely involved in intestinal carcinogenesis. A marked reduction
in butyrate-producing bacteria has been observed in patients with colorectal cancer (CRC); …

Primary bile acids serve important roles in cholesterol metabolism, lipid digestion, host-
microbe interactions, and regulatory pathways in the human host. While most bile acids are …

Neoplasms change over time through a process of cell-level evolution, driven by genetic
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …

Globally breast cancer is the leading cause of cancer death among women. The breast
consists of epithelium, stroma and a mucosal immune system that make up a complex …

Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …