Cerebral cavernous malformation: from mechanism to therapy

DA Snellings, CC Hong, AA Ren… - Circulation …, 2021 - Am Heart Assoc
Cerebral cavernous malformations are acquired vascular anomalies that constitute a
common cause of central nervous system hemorrhage and stroke. The past 2 decades have …

Synopsis of guidelines for the clinical management of cerebral cavernous malformations: consensus recommendations based on systematic literature review by the …

A Akers, RAS Salman, IA Awad, K Dahlem… - …, 2017 - journals.lww.com
BACKGROUND: Despite many publications about cerebral cavernous malformations
(CCMs), controversy remains regarding diagnostic and management strategies …

Childhood stroke

PB Sporns, HJ Fullerton, S Lee, H Kim, WD Lo… - Nature Reviews …, 2022 - nature.com
Stroke is an important cause of neurological morbidity in children; most survivors have
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …

Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations

T Hong, X **ao, J Ren, B Cui, Y Zong, J Zou, Z Kou… - Brain, 2021 - academic.oup.com
Cavernous malformations affecting the CNS occur in∼ 0.16–0.4% of the general population.
The majority (85%) of cavernous malformations are in a sporadic form, but the genetic …

Cavernous angiomas: deconstructing a neurosurgical disease: JNSPG 75th Anniversary Invited Review Article

IA Awad, SP Polster - Journal of neurosurgery, 2019 - thejns.org
Cavernous angioma (CA) is also known as cavernoma, cavernous hemangioma, and
cerebral cavernous malformation (CCM)(National Library of Medicine Medical Subject …

Familial cerebral cavernous malformations

A Zafar, SA Quadri, M Farooqui, A Ikram, M Robinson… - Stroke, 2019 - Am Heart Assoc
surface interactions between these as well as with numerous binding partners. 17 FCCM is
inherited in an autosomal dominant fashion, with every affected parent having a 50 …

Cerebral cavernous malformation: what a practicing clinician should know

KD Flemming, G Lanzino - Mayo Clinic Proceedings, 2020 - Elsevier
Cavernous malformations (CMs) are angiographically occult, low-flow vascular
malformations of the central nervous system. They are acquired lesions, with approximately …

Natural history of cavernous malformation: systematic review and meta-analysis of 25 studies

S Taslimi, A Modabbernia, S Amin-Hanjani, FG Barker… - Neurology, 2016 - AAN Enterprises
Objective: We pooled the results of studies on natural history of cavernous malformations
(CM) to calculate point estimates and investigate main sources of heterogeneity. Methods …

Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation: a multi-institutional, retrospective study

C Dumot, G Mantziaris, S Dayawansa, Z Xu… - Stroke and Vascular …, 2024 - svn.bmj.com
Background Cerebral cavernous malformations (CCMs) frequently manifest with
haemorrhages. Stereotactic radiosurgery (SRS) has been employed for CCM not suitable for …

Nontraumatic intracerebral haemorrhage in young adults

T Tatlisumak, B Cucchiara, S Kuroda… - Nature Reviews …, 2018 - nature.com
Nontraumatic intracerebral haemorrhage (ICH) is a common subtype of stroke with a poor
prognosis, high mortality and long-term morbidity. The incidence of ICH increases with age …