Cellular reprogramming dynamics follow a simple 1D reaction coordinate

ST Pusuluri, AH Lang, P Mehta, HE Castillo - Physical Biology, 2017 - iopscience.iop.org
Cellular reprogramming, the conversion of one cell type to another, induces global changes
in gene expression involving thousands of genes, and understanding how cells globally …

Similarity measure for sparse time course data based on Gaussian processes

Z Liu, M Barahona - Uncertainty in Artificial Intelligence, 2021 - proceedings.mlr.press
We propose a similarity measure for sparsely sampled time course data in the form of a log-
likelihood ratio of Gaussian processes (GP). The proposed GP similarity is similar to a Bayes …

FGF signaling and cell state transitions during organogenesis

E Gallo - 2023 - archiv.ub.uni-heidelberg.de
Organogenesis is a complex choreography of morphogenetic processes, patterns and
dynamic shape changes as well as the specification of cell fates. Although several molecular …

Exploring Neural Network Models with Hierarchical Memories and Their Use in Modeling Biological Systems

ST Pusuluri - 2017 - rave.ohiolink.edu
Energy landscapes are often used as metaphors for phenomena in biology, social sciences
and finance. Different methods have been implemented in the past for the construction of …

Cellular reprogramming dynamics follow a simple one-dimensional reaction coordinate

ST Pusuluri, AH Lang, P Mehta, HE Castillo - arxiv preprint arxiv …, 2015 - arxiv.org
Cellular reprogramming, the conversion of one cell type to another, has fundamentally
transformed our conception of cell types. Cellular reprogramming induces global changes in …

Physics of epigenetic landscapes and statistical inference by cells

AH Lang - Ph. D. Thesis, 2015 - ui.adsabs.harvard.edu
Biology is currently in the midst of a revolution. Great technological advances have led to
unprecedented quantitative data at the whole genome level. However, new techniques are …