Abstract More than 2.1 million age-related fractures occur in the United States annually,
resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of …

Bones comprise a significant percentage of human weight and have important physiologic
and structural roles. Bone remodeling occurs when healthy bone is renewed to maintain …

Bone fracture healing: is an intricate and fluent regenerative process that aims at restoring
the damaged bone to its pre-injury state and cellular composition.[1] A fracture is a breach in …

Senescent cells have detrimental effects across tissues with aging but may have beneficial
effects on tissue repair, specifically on skin wound healing. However, the potential role of …

Glucocorticoid-induced osteoporosis update : Current Opinion in Rheumatology
Glucocorticoid-induced osteoporosis update : Current Opinion in Rheumatology Log in or …

Cells expressing features of senescence, including upregulation of p21 and p16, appear
transiently following tissue injury, yet the properties of these cells or how they contrast with …

Background: The nonpsychotropic phytocannabinoid cannabidiol (CBD) presents itself as a
potentially safe and effective anti-inflammatory treatment relative to clinical standards. In this …

Delayed fracture healing and fracture non-unions impose an enormous burden on
individuals and society. Successful healing requires tight communication between immune …

Abstract Purpose of Review Describe the potential contribution of disorganized tissue to the
pathogenesis of bone abnormalities and fractures. Especially, fractures that are unexplained …

Glucocorticoids (GCs) are steroid hormones that respond to stress and the circadian rhythm.
Pharmacological GCs are widely used to treat autoimmune and chronic inflammatory …