RNA-based liquid biopsy in head and neck cancer
J Kabzinski, A Kucharska-Lusina, I Majsterek - Cells, 2023 - mdpi.com
Head and neck cancer (HNC) is a prevalent and diverse group of malignancies with
substantial morbidity and mortality rates. Early detection and monitoring of HNC are crucial …
substantial morbidity and mortality rates. Early detection and monitoring of HNC are crucial …
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
Cultured cell lines are the workhorse of cancer research, but the extent to which they
recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here …
recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here …
Precision medicine approaches to overcome resistance to therapy in head and neck cancers
Head and neck squamous cell carcinoma (HNSCC) is the sixth most incident cancer
worldwide. More than half of HNSCC patients experience locoregional or distant relapse to …
worldwide. More than half of HNSCC patients experience locoregional or distant relapse to …
A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer
H Schinke, E Shi, Z Lin, T Quadt, G Kranz, J Zhou… - Molecular Cancer, 2022 - Springer
Background Epidermal growth factor receptor (EGFR) is both a driver oncogene and a
therapeutic target in advanced head and neck squamous cell carcinoma (HNSCC) …
therapeutic target in advanced head and neck squamous cell carcinoma (HNSCC) …
BET inhibition overcomes receptor tyrosine kinase–mediated cetuximab resistance in HNSCC
B Leonard, TM Brand, RA O'Keefe, ED Lee, Y Zeng… - Cancer research, 2018 - AACR
Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell
carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and …
carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and …
Enabling Single‐Cell Drug Response Annotations from Bulk RNA‐Seq Using SCAD
The single‐cell RNA sequencing (scRNA‐seq) quantifies the gene expression of individual
cells, while the bulk RNA sequencing (bulk RNA‐seq) characterizes the mixed transcriptome …
cells, while the bulk RNA sequencing (bulk RNA‐seq) characterizes the mixed transcriptome …
DDX3 activates CBC-eIF3–mediated translation of uORF-containing oncogenic mRNAs to promote metastasis in HNSCC
HH Chen, HI Yu, MH Yang, WY Tarn - Cancer research, 2018 - AACR
Mutated or dysregulated DDX3 participates in the progression and metastasis of cancer via
its multiple roles in regulating gene expression and cellular signaling. Here, we show that …
its multiple roles in regulating gene expression and cellular signaling. Here, we show that …
Therapy-related transcriptional subtypes in matched primary and recurrent head and neck cancer
Purpose: The genetic relatedness between primary and recurrent head and neck squamous
cell carcinomas (HNSCC) reflects the extent of heterogeneity and therapy-driven selection of …
cell carcinomas (HNSCC) reflects the extent of heterogeneity and therapy-driven selection of …
TGF-beta-activated cancer-associated fibroblasts limit cetuximab efficacy in preclinical models of head and neck cancer
Most head and neck cancer (HNC) patients are resistant to cetuximab, an antibody against
the epidermal growth factor receptor. Such therapy resistance is known to be mediated, in …
the epidermal growth factor receptor. Such therapy resistance is known to be mediated, in …
Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway
R Garcia-Escudero, C Segrelles, M Duenas, M Pombo… - Oral Oncology, 2018 - Elsevier
Objectives Phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) is commonly
altered in many human tumors, leading to the activation of p110α enzymatic activity that …
altered in many human tumors, leading to the activation of p110α enzymatic activity that …