Exposure to airborne particulate matter (PM) has been associated with detrimental health
effects. DNA methylation represents the most well-studied epigenetic factor among the …

Due to its convenience, the blood is commonly used in epigenomic studies, but its
heterogeneous nature leads to interpretation difficulties, given the now widely recognized …

Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …

PURPOSE The utility of circulating tumor DNA (ctDNA) analyses has not been established in
the risk stratification of Wilms tumor (WT). We evaluated the detection of ctDNA and selected …

Background The impact of cell-composition effects in analysis of DNA methylation data is
now widely appreciated. With the availability of a reference data set consisting of DNA …

Wilms tumour (WT) is the most common paediatric kidney cancer and affects approximately
one in 10 000 children. The tumour is associated with undifferentiated embryonic lesions …

Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with
potential applications during all stages of patient care, from diagnosis to long-term follow-up …

Peripheral circulating free DNA (cfDNA) is DNA that is detected in plasma or serum fluid with
a cell-free status. For cancer patients, cfDNA not only originates from apoptotic cells but also …

Pediatric solid tumors have long been known to shed tumor cells, DNA, RNA, and proteins
into the blood. Recent technological advances have allowed for improved capture and …

Circulating tumor DNA can be detected in the blood and body fluids of patients using
ultrasensitive technologies, which have the potential to improve cancer diagnosis, risk …