During the development of peripheral nerves, neural crest cells generate myelinating and
non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of …

Cranial placodes are focal regions of thickened ectoderm in the head of vertebrate embryos
that give rise to a wide variety of cell types, including elements of the paired sense organs …

We have studied the role of Notch-1 and its antagonist Numb in the activation of satellite
cells during postnatal myogenesis. Activation of Notch-1 promoted the proliferation of …

The molecular mechanisms that determine glial cell fate in the vertebrate nervous system
have not been elucidated. Peripheral glial cells differentiate from pluripotent neural crest …

The cells of the neural crest, often referred to as neural crest stem cells, give rise to a
number of sub-lineages, one of which is Schwann cells, the glial cells of peripheral nerves …

We have addressed the role of the proneural bHLH genes Neurogenin2 (Ngn2) and Mash1
in the selection of neuronal and glial fates by neural stem cells. We show that mice mutant …

Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-
inducible factors (HIF) 1α and HIF-2α are key transcription regulators of phenotypic …

Notch signaling is central to vertebrate development, and analysis of Notch has provided
important insights into pathogenetic mechanisms in the CNS and many other tissues …

Stem cells and neuroblasts derived from mouse embryos undergo repeated asymmetric cell
divisions, generating neural lineage trees similar to those of invertebrates. In Drosophila …

The winged-helix or forkhead class of transcription factors has been shown to play important
roles in cell specification and lineage segregation. We have cloned the chicken homolog of …