Seronegative autoimmune diseases: A challenging diagnosis

MV Lenti, CM Rossi, F Melazzini, M Gastaldi… - Autoimmunity …, 2022 - Elsevier
Autoimmune diseases (AID) are increasingly prevalent conditions which comprise more
than 100 distinct clinical entities that are responsible for a great disease burden worldwide …

Origins and immunopathogenesis of autoimmune central nervous system disorders

S Ramanathan, F Brilot, SR Irani, RC Dale - Nature Reviews Neurology, 2023 - nature.com
The field of autoimmune neurology is rapidly evolving, and recent discoveries have
advanced our understanding of disease aetiologies. In this article, we review the key …

Neurological adverse events of immune checkpoint inhibitors and the development of paraneoplastic neurological syndromes

A Farina, M Villagrán-García, A Vogrig… - The Lancet …, 2024 - thelancet.com
Immune checkpoint inhibitors, a class of oncological treatments that enhance antitumour
immunity, can trigger neurological adverse events closely resembling paraneoplastic …

Clinical, serological and genetic predictors of response to immunotherapy in anti-IgLON5 disease

T Grüter, FE Möllers, A Tietz, J Dargvainiene, N Melzer… - Brain, 2023 - academic.oup.com
Anti-IgLON5 disease is a newly defined clinical entity characterized by a progressive course
with high disability and mortality rate. While precise pathogenetic mechanisms remain …

Neurological outcomes in immune checkpoint inhibitor-related neurotoxicity

A Farina, C Birzu, MH Elsensohn, A Picca… - Brain …, 2023 - academic.oup.com
While the spectrum of neurological immune checkpoint inhibitor-related adverse events is
expanding, patients' outcomes are not well documented. This study aimed to assess …

Paraneoplastic neurological syndromes: a practical approach to diagnosis and management

S Binks, C Uy, J Honnorat, SR Irani - Practical Neurology, 2022 - pn.bmj.com
Paraneoplastic neurological syndromes (PNS) are the immune-mediated effects of a remote
cancer and are characterised by an autoantibody response against antigens expressed by …

Mimics of autoimmune encephalitis: validation of the 2016 clinical autoimmune encephalitis criteria

RW Van Steenhoven, JM de Vries… - Neurology …, 2023 - neurology.org
Background and Objectives The clinical criteria for autoimmune encephalitis (AE) were
proposed by Graus et al. in 2016. In this study, the AE criteria were validated in the real …

Paraneoplastic neurologic disorders

M Gilligan, C McGuigan, A McKeon - Current neurology and neuroscience …, 2023 - Springer
Abstract Purpose of Review To provide an overview and highlight recent updates in the field
of paraneoplastic neurologic disorders. Recent Findings The prevalence of paraneoplastic …

Anti-Hu antibodies in patients with neurologic side effects of immune checkpoint inhibitors

A Farina, M Villagrán-García… - Neurology …, 2022 - neurology.org
Background and Objectives To clinically characterize post–immune checkpoint inhibitor (ICI)
Hu antibody (Ab) neurologic disorders, we analyzed Hu-Ab–positive patients with …

Paraneoplastic neurological syndromes of the central nervous system: pathophysiology, diagnosis, and treatment

L Marsili, S Marcucci, J LaPorta, M Chirra, AJ Espay… - Biomedicines, 2023 - mdpi.com
Paraneoplastic neurological syndromes (PNS) include any symptomatic and non-metastatic
neurological manifestations associated with a neoplasm. PNS associated with antibodies …