The dentato-rubro-olivary pathway, also known as the Guillain-Mollaret triangle (GMT) or
myoclonic triangle, consists of the dentate nucleus, the red nucleus, and the inferior olivary …

Leigh syndrome by definition is (1) a neurodegenerative disease with variable symptoms,(2)
caused by mitochondrial dysfunction from a hereditary genetic defect and (3) accompanied …

Abstract Human 4-hydroxyphenylpyruvate dioxygenase-like (HPDL) is a putative iron-
containing non-heme oxygenase of unknown specificity and biological significance. We …

Abstract Peroxiredoxin 3 (PRDX3) belongs to a superfamily of peroxidases that function as
protective antioxidant enzymes. Among the six isoforms (PRDX1–PRDX6), PRDX3 is the …

Introduction The frequency and causes of hypertrophic olivary degeneration (HOD) are
unknown. We compared the clinical and radiological characteristics of unilateral HOD and …

Hypertrophic olivary degeneration (HOD) is a transsynaptic degeneration of the nervous
system caused by lesions of the dentato-rubro-olivary pathway (DROP)(1). Typically, HOD …

ABSTRACT PURPOSE Investigate the relative frequency of nonlesional versus lesional
hypertrophic olivary degeneration (HOD) and potential explanations for nonlesional HOD …

Background TTC19 deficiency is a progressive neurodegenerative disease associated with
isolated mitochondrial respiratory chain (MRC) complex III deficiency and loss-of-function …

Background Large studies analyzing magnetic resonance imaging correlates in different
genotypes of mitochondrial disorders are far and few. This study sought to analyze the …

Background Hypertrophic olivary degeneration (HOD) is a unique type of neuronal
degeneration presenting as hypertrophy, in contrast to atrophy as seen in most cases. It …