STAT proteins in cancer: orchestration of metabolism
YJ Li, C Zhang, A Martincuks, A Herrmann… - Nature reviews Cancer, 2023 - nature.com
Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …
cancer, from tumour initiation through disease progression and therapy resistance, requires …
Recent update on development of small-molecule STAT3 inhibitors for cancer therapy: from phosphorylation inhibition to protein degradation
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that
regulates various biological processes, including proliferation, metastasis, angiogenesis …
regulates various biological processes, including proliferation, metastasis, angiogenesis …
Neuroprotective mechanisms of resveratrol in Alzheimer's disease: role of SIRT1
BAQ Gomes, JPB Silva, CFR Romeiro… - Oxidative medicine …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a progressive and neurodegenerative disorder of the cortex and
hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD …
hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD …
Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment
Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …
characterized by the progressive degeneration of the function and structure of the central …
Metformin improves healthspan and lifespan in mice
Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we
show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age …
show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age …
Redox regulation of SIRT1 in inflammation and cellular senescence
J Hwang, H Yao, S Caito, IK Sundar… - Free Radical Biology and …, 2013 - Elsevier
Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …
Mitochondria‐ros crosstalk in the control of cell death and aging
Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …
Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer's disease from bench to bedside
Alzheimer's disease (AD) is the most common cause of dementia and cognitive impairment;
yet, there is currently no treatment. A buildup of Aβ, tau protein phosphorylation, oxidative …
yet, there is currently no treatment. A buildup of Aβ, tau protein phosphorylation, oxidative …
Evidence for a common mechanism of SIRT1 regulation by allosteric activators
A molecule that treats multiple age-related diseases would have a major impact on global
health and economics. The SIRT1 deacetylase has drawn attention in this regard as a target …
health and economics. The SIRT1 deacetylase has drawn attention in this regard as a target …
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
The prevention or delay of the onset of age-related diseases prolongs survival and improves
quality of life while reducing the burden on the health care system. Activation of sirtuin 1 …
quality of life while reducing the burden on the health care system. Activation of sirtuin 1 …