Without any exaggeration, cholesterol is one of the most important lipid species in eukaryotic
cells. Its effects on cellular membranes and functions range from purely mechanistic to …

Mammalian cells acquire cholesterol from low-density lipoprotein (LDL) and from
endogenous biosynthesis. The roles of the Niemann-Pick type C1 protein in mediating the …

Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol‐
rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain …

Lipid rafts are specialized membrane microdomains that serve as organizing centers for
assembly of signaling molecules, influence membrane fluidity and trafficking of membrane …

The relative stability of cholesterol in cellular membranes and the thermodynamics of
fluctuations from equilibrium have important consequences for sterol trafficking and lateral …

This review summarizes the mechanisms of cellular cholesterol transport and monogenic
human diseases caused by defects in intracellular cholesterol processing. In addition …

Lipids rafts are considered to be functional nanoscale membrane domains enriched in
cholesterol and sphingolipids, characteristic in particular of the external leaflet of cell …

The paradigm of biological membranes has recently gone through a major update. Instead
of being fluid and homogeneous, recent studies suggest that membranes are characterized …

Analysis of sterol distribution and transport in living cells has been hampered by the lack of
bright, photostable fluorescent sterol derivatives that closely resemble cholesterol. In this …

The multiple actions of U18666A have enabled major discoveries in lipid research and
contributed to understanding the pathophysiology of multiple diseases. This review …