Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …

A DNA triplex is formed when pyrimidine or purine bases occupy the major groove of the
DNA double Helix forming Hoogsteen pairs with purines of the Watson-Crick basepairs …

We have discovered that single-stranded DNA containing short guanine-rich motifs will self-
associate at physiological salt concentrations to make four-stranded structures in which the …

Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …

THE telomeric ends of eukaryotic chromosomes are composed of simple repeating
sequences in which one DNA strand contains short tracts of guanine residues alternating …

The c-myc oncogene is one of the most commonly malfunctioning genes in human cancers,
and is an attractive target for anti-gene therapy. Although synthetic oligonucleotides …

In biology, nucleic acids are carriers of molecular information: DNA's base sequence stores
and imparts genetic instructions, while RNA's sequence plays the role of a messenger and a …

Approximately 13% of the human genome can fold into non-canonical (non-B) DNA
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …

Kearns-Sayre syndrome (KSS) and progressive external ophthalmoplegia (PEO) are related
neuromuscular disorders characterized by ocular myopathy and ophthalmoplegia. Almost all …

Nucleic acids can be selectively recognized by a large number of natural and synthetic
ligands. Oligonucleotides provide the highest specificity of recognition. They can bind to a …