Global epidemiology and genetics of hepatocellular carcinoma

MR Toh, EYT Wong, SH Wong, AWT Ng, LH Loo… - Gastroenterology, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC
develops in genetically susceptible individuals who are exposed to risk factors, especially in …

[HTML][HTML] The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

TH Karlsen, N Sheron, S Zelber-Sagi, P Carrieri… - The Lancet, 2022 - thelancet.com
Executive summary Liver diseases have become a major health threat across Europe, and
the face of European hepatology is changing due to the cure of viral hepatitis C and the …

Progress towards elimination goals for viral hepatitis

AL Cox, MH El-Sayed, JH Kao, JV Lazarus… - Nature reviews …, 2020 - nature.com
The global burden of viral hepatitis is substantial; in terms of mortality, hepatitis B virus and
hepatitis C virus infections are on a par with HIV, malaria and tuberculosis, among the top …

The contribution of injection drug use to hepatitis C virus transmission globally, regionally, and at country level: a modelling study

A Trickey, H Fraser, AG Lim, A Peacock… - The lancet …, 2019 - thelancet.com
Background WHO aims to eliminate the hepatitis C virus (HCV) as a public health threat by
2030. Injection drug use is an important risk factor for HCV transmission, but its contribution …

Hepatitis C: Is eradication possible?

A Lombardi, MU Mondelli… - Liver …, 2019 - Wiley Online Library
Hepatitis C has a relevant global impact in terms of morbidity, mortality and economic costs,
with more than 70 million people infected worldwide. In the resolution,“Transforming our …

[HTML][HTML] Treatment as prevention effect of direct-acting antivirals on primary hepatitis C virus incidence: findings from a multinational cohort between 2010 and 2019

DK van Santen, R Sacks-Davis, A Stewart, A Boyd… - …, 2023 - thelancet.com
Background Broad direct-acting antiviral (DAA) access may reduce hepatitis C virus (HCV)
incidence through a" treatment as prevention"(TasP) effect. We assessed changes in …

[HTML][HTML] Hepatocellular carcinoma prevention in the era of hepatitis C elimination

JV Lazarus, CA Picchio, M Colombo - International Journal of Molecular …, 2023 - mdpi.com
The hepatitis C virus (HCV), a single-stranded RNA virus belonging to the Flaviviridae
family, is a major cause of hepatocellular carcinoma (HCC) worldwide. Tumors caused by …

Decline in hepatitis C virus (HCV) incidence in men who have sex with men living with human immunodeficiency virus: progress to HCV microelimination in the United …

LJ Garvey, GS Cooke, C Smith… - Clinical Infectious …, 2021 - academic.oup.com
Abstract Background Modeling of the London hepatitis C virus (HCV) epidemic in men who
have sex with men (MSM) and are living with human immunodeficiency virus (HIV) …

Epidemiology of hepatitis C virus infection in a country with universal access to direct‐acting antiviral agents: data for designing a cost‐effective elimination policy in …

J Crespo, A Cuadrado, C Perelló… - Journal of viral …, 2020 - Wiley Online Library
Accurate HCV prevalence estimates are necessary for guiding elimination policies. Our aim
was to determine the HCV prevalence and assess the cost‐effectiveness of a screen‐and …

Reinfection with the hepatitis C virus in men who have sex with men after successful treatment with direct-acting antivirals in Germany: current incidence rates …

P Ingiliz, MH Wehmeyer, C Boesecke… - Clinical Infectious …, 2020 - academic.oup.com
Background Micro-elimination of the hepatitis C virus (HCV) includes treatment in
populations at risk of ongoing HCV transmission, such as men who have sex with men …