The gut microbiota and its biogeography

G McCallum, C Tropini - Nature Reviews Microbiology, 2024 - nature.com
Biogeography is the study of species distribution and diversity within an ecosystem and is at
the core of how we understand ecosystem dynamics and interactions at the macroscale. In …

Microbiota-mediated colonization resistance: mechanisms and regulation

G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …

Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis

X Wang, S Lin, L Wang, Z Cao, M Zhang, Y Zhang… - Science …, 2023 - science.org
Outer membrane vesicles (OMVs) play vital roles in bacterial communication both
intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota …

Dietary fiber and SCFAs in the regulation of mucosal immunity

JK Tan, L Macia, CR Mackay - Journal of allergy and clinical immunology, 2023 - Elsevier
Gut bacterial metabolites such as short-chain fatty acids (SCFAs) have important effects on
immune cells and the gut. SCFAs derive from the fermentation of dietary fiber by gut …

Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Antimicrobial properties of chitosan and chitosan derivatives in the treatment of enteric infections

D Yan, Y Li, Y Liu, N Li, X Zhang, C Yan - Molecules, 2021 - mdpi.com
Antibiotics played an important role in controlling the development of enteric infection.
However, the emergence of antibiotic resistance and gut dysbiosis led to a growing interest …

Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

HS Yoon, CH Cho, MS Yun, SJ Jang, HJ You… - Nature …, 2021 - nature.com
The gut microbiota, which includes Akkermansia muciniphila, is known to modulate energy
metabolism, glucose tolerance, immune system maturation and function in humans …

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

KS Swanson, GR Gibson, R Hutkins… - Nature Reviews …, 2020 - nature.com
Abstract In May 2019, the International Scientific Association for Probiotics and Prebiotics
(ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the …

Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria

Y Chen, S Lin, L Wang, Y Zhang, H Chen… - Nature Biomedical …, 2024 - nature.com
The breakdown of the gut's mucosal barrier that prevents the infiltration of microorganisms,
inflammatory cytokines and toxins into bodily tissues can lead to inflammatory bowel …

Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome

J Xu, J Xu, T Shi, Y Zhang, F Chen, C Yang… - Advanced …, 2023 - Wiley Online Library
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …