Causes and consequences of centrosome abnormalities in cancer

SA Godinho, D Pellman - Philosophical Transactions of …, 2014 - royalsocietypublishing.org
Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

[HTML][HTML] Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), a neoplasm of CD4+ CD25+ T cells that occurs in 2–5% of …

The HTLV-1 tax interactome

M Boxus, JC Twizere, S Legros, JF Dewulf, R Kettmann… - Retrovirology, 2008 - Springer
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant
of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling …

How I treat adult T-cell leukemia/lymphoma

A Bazarbachi, F Suarez, P Fields… - Blood, The Journal of …, 2011 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of mature activated T
cells caused by human T-cell lymphotropic virus type I. ATL carries a bad prognosis …

[HTML][HTML] Molecular mechanisms of HTLV-1 cell-to-cell transmission

C Gross, AK Thoma-Kress - Viruses, 2016 - mdpi.com
The tumorvirus human T-cell lymphotropic virus type 1 (HTLV-1), a member of the delta-
retrovirus family, is transmitted via cell-containing body fluids such as blood products …

HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

R Currer, R Van Duyne, E Jaworski, I Guendel… - Frontiers in …, 2012 - frontiersin.org
Human T-cell lymphotropic virus type 1 (HTLV-1) has been identified as the causative agent
of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic …

Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer

AJ Wiecek, SJ Cutty, D Kornai, M Parreno-Centeno… - Genome Biology, 2023 - Springer
Background Therapy resistance in cancer is often driven by a subpopulation of cells that are
temporarily arrested in a non-proliferative G0 state, which is difficult to capture and whose …

[HTML][HTML] HTLV-1 infection and pathogenesis: new insights from cellular and animal models

G Forlani, M Shallak, RS Accolla… - International Journal of …, 2021 - mdpi.com
Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal
models have provided invaluable contributions in the knowledge of viral infection …

Primary cells from patients with adult T cell leukemia/lymphoma depend on HTLV-1 Tax expression for NF-κB activation and survival

R Hleihel, H Skayneh, H de Thé, O Hermine… - Blood Cancer …, 2023 - nature.com
Adult T cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic
infection with human T cell leukemia virus type 1 (HTLV-1). The viral oncoprotein Tax …

Novel treatments of adult T cell leukemia lymphoma

H El Hajj, K Tsukasaki, M Cheminant… - Frontiers in …, 2020 - frontiersin.org
Adult T cell leukemia-lymphoma (ATL) is an aggressive malignancy secondary to chronic
infection with the human T cell leukemia virus type I (HTLV-I) retrovirus. ATL carries a dismal …