Neuroinflammation is a physiological protective response in the context of infection and
injury. However, neuroinflammation, especially if chronic, may also drive …

Progesterone has a broad spectrum of actions in the brain. Among these, the
neuroprotective effects are well documented. Progesterone neural effects are mediated by …

Abstract Allopregnanolone, a 3α, 5α‐progesterone metabolite, acts as a potent allosteric
modulator of the γ‐aminobutyric acid type A receptor. In the present review, the synthesis of …

Sleep deprivation negatively influences all aspects of health. Oxidative stress and
inflammatory responses induced by sleep deprivation participate in its adverse effects but …

With each passing year, the number of people suffering from mental disorders grows at a
disturbing speed. Neuroactive steroids are a new promising group of drugs with the potential …

Introduction: Asthma is related to neurochemical alterations which affect brain functions and
lead to anxiety and cognitive dysfunctions. Myrtenol has sparked considerable interest due …

Persistent neuroinflammation is now recognized as a chief pathological component of
practically all neurodegenerative diseases. Neuroinflammation in the central nervous …

Neuroactive steroids can be synthetic or endogenous molecules produced by neuronal and
glial cells and peripheral glands. Examples include estrogens, testosterone, progesterone …

Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit
efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation …

Neuroactive steroids are known neuroprotective agents and neurotransmitter regulators. We
previously found that expression of the enzymes synthesizing 5α-dihydroprogesterone (5α …